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CD28 co-stimulation regulates the effect of transforming growth factor-β1 on the proliferation of naı̈ve CD4+ T cells

✍ Scribed by James L Sung; Jack T Lin; James D Gorham


Book ID
117798155
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
255 KB
Volume
3
Category
Article
ISSN
1567-5769

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The role of TGF-g 1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-g 1 has a profound inhibitory effect on naive CD4 + T cell undergoing