The interaction of CD28 with its counter-receptor, B7-1 (CD 80), on antigenpresenting cells induces a co-signal in T cells required to promote antigendependent interleukin-2 (IL-2) production and to prevent clonal anergy. CD28 stimulation causes both protein-tyrosine kinase and phosphatidylinositol3
โฆ LIBER โฆ
CD28 can promote T cell survival through a phosphatidylinositol 3-kinase-independent mechanism
โ Scribed by Yves Collette; D. Razanajaona; M. Ghiotto; Daniel Olive
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 927 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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We investigated the possible involvement of HTLV-1 Tax in the transcriptional activation of p21/Waf1/Cip1 (hereafter p21), a potent inhibitor of cyclin-dependent kinases and cell growth. Tax transfection resulted in enhanced expression of p21 protein in T and fibroblastoid cells. Similarly, Tax-expr