CD200 Immunoadhesin Suppresses Collagen-Induced Arthritis in Mice
β Scribed by Reginald M. Gorczynski; Zhiqi Chen; Kai Yu; Jiang Hu
- Book ID
- 115593861
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 108 KB
- Volume
- 101
- Category
- Article
- ISSN
- 1090-2341
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π SIMILAR VOLUMES
## Abstract ## Objective To examine whether systemic administration of oligonucleotides (ODNs), known to inhibit the production of proinflammatory cytokines, alters host susceptibility to collagenβinduced arthritis (CIA), a murine model of rheumatoid arthritis (RA). ## Methods CIA was induced by
We have previously reported that male DBM1 mice are more susceptible to collagen-induced arthritis than are females. Here we report that oophorectomy makes female mice as susceptible to collagen arthritis as are normal males. Induction of collagen-induced arthritis in mice is a T cellaependent proce