𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CD147 regulates vascular endothelial growth factor—A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma

✍ Scribed by Li Jia; Huaxin Wang; Shuxian Qu; Xiaoyan Miao; Jianing Zhang

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
259 KB
Volume
60
Category
Article
ISSN
1521-6543

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

CD147, also named as extracelluar matrix metalloproteinase inducer (EMMPRIN), has been proved to be involved in several aspects of tumor progression. In addition to its ability to induce vascular endothelial growth factor (VEGF) production, it confers resistance to some chemotherapeutic drugs. To investigate the possible role of CD147 in the mouse hepatocarcinoma cell line Hepa1‐6 with no metastatic potential in the lymph nodes, we used RNA interference (RNAi) approach to silence CD147 expression. The results showed that silencing of CD147 in Hepa1‐6 cells significantly impeded the expression of VEGF‐A at both mRNA and protein levels. The siRNA‐treated cells exhibited significantly decreased growth ability when compared with control cells. Colony formation of CD147 deficient cells was dramatically inhibited in soft agar, and tumorigenicity was reduced in nude mice. Furthermore, the downregulation of CD147 expression also sensitized cells to be more sensitive to curcumin. These results suggested that CD147 might be a potential target for therapeutic antitumor drugs. © 2007 IUBMB IUBMB Life, 60(1): 57–63, 2008

📜 SIMILAR VOLUMES

Vascular endothelial growth factor tight
Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cells
✍ Hitoshi Yoshiji; Shigeki Kuriyama; Junichi Yoshii; Masaharu Yamazaki; Masaji Kik 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB

## Angiogenesis is essential for the development of a solid tumor, including hepatocellular carcinoma (HCC). HCC is a well-known hypervascular tumor. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors. Its role has not been clarified in vivo in HCC development.

Vascular endothelial growth factor expre
Vascular endothelial growth factor expression in early stage ovarian carcinoma
✍ Pamela J. Paley; Katherine A. Staskus; Kristin Gebhard; Dhanabal Mohanraj; Leo B 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB 👁 2 views

VEGF expression. Antisense and corresponding sense (control) RNA probes were transcribed from the pCRII construct (Invitrogen, San Diego, CA), which con-

KDR/Flk-1 is a major regulator of vascul
KDR/Flk-1 is a major regulator of vascular endothelial growth factor–induced tumor development and angiogenesis in murine hepatocellular carcinoma cells
✍ Hitoshi Yoshiji; Shigeki Kuriyama; Daniel J. Hicklin; James Huber; Junichi Yoshi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB

Vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors, has been shown to play a pivotal role in tumor angiogenesis, including hepatocellular carcinoma (HCC). The effects of VEGF are mediated mainly through two distinct receptors, flt-1 and KDR/ Flk-1. It has b

Vascular endothelial growth factor-induc
Vascular endothelial growth factor-induced tumor angiogenesis and tumorigenicity in relation to metastasis in a HT1080 human fibrosarcoma cell model
✍ Akira Mori; Shigeki Arii; Masaharu Furutani; Koji Hanaki; Yoshihisa Takeda; Take 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 260 KB 👁 1 views

Although vascular endothelial growth factor (VEGF) is well known to be a potent mitogen for vascular endothelial cells, the role of VEGF in a developmental process of tumor angiogenesis and metastatic potential remains poorly understood. The present study was designed to investigate VEGFinduced vasc