✦ LIBER ✦

CCNU and bleomycin in the treatment of cancer: A southwest oncology group study

✍ Scribed by Hoogstraten, Barth ;Haas, Charles D. ;Haut, Arthur ;Talley, Robert W. ;Rivkin, Saul ;Isaacs, Bertha L.

Publisher: John Wiley and Sons
Year: 1975
Tongue: English
Weight: 570 KB
Volume: 1
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950010204

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✦ Synopsis

Abstract

CCNU and Bleomycin, alone or in combination, were used to treat 397 evaluable cases of advanced cancer. Responses defined as 50% or greater reduction in all tumor masses occurred in 13/35 lymphomas, 8/50 brain cancers, and 28/312 other solid tumors. Hematologic toxicity of a life‐threatening degree occurred in 33/298 patients evaluable for CCNU toxicity; in an additional 50 it was considered severe. Pulmonary toxicity was severe in 4 patients. Drug‐associated deaths (4) included one each due to leukopenia and thrombocytopenia after CCNU; one due to pulmonary toxicity after Bleomycin; and one due to shock after the 20th dose of Bleomycin. There was no suggestion of synergism or additive activity with the two drugs.

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