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CCAAT/enhancer binding proteins α and β regulate the tumor necrosis factor receptor 1 gene promoter

✍ Scribed by Jillian A. Bristol; Thomas E. Morrison; Shannon C. Kenney

Book ID
116757348
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
549 KB
Volume
46
Category
Article
ISSN
0161-5890

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The sensitization of hepatocytes to cell death from tumor necrosis factor α (TNFα) underlies many forms of hepatic injury, including that from toxins. Critical for hepatocyte resistance to TNFα toxicity is activation of nuclear factor κB (NF-κB) signaling, which prevents TNFα-induced death by the up