Cbfa1/Runx2-deficiency delays bone wound healing and locally delivered Cbfa1/Runx2 promotes bone repair in animal models

Overexpression of Runx2 directed by the

Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo

✍ Nagarajan Selvamurugan; Stephen C. Jefcoat; Sukyee Kwok; Rodney Kowalewski; Jose 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 467 KB 👁 1 views

## Abstract The activator protein‐1 (AP‐1) and __runt__ domain binding (Runx/RD/Cbfa) sites and their respective binding proteins, c‐Fos/c‐Jun and Runx2 (Cbfa1), regulate the rat matrix metalloproteinase‐13 (MMP‐13) promoter in both parathyroid hormone (PTH)‐treated and differentiating osteoblastic