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Cbfa1 as a regulator of osteoblast differentiation and function

✍ Scribed by G Karsenty; P Ducy; M Starbuck; M Priemel; J Shen; V Geoffroy; M Amling


Book ID
117808891
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
34 KB
Volume
25
Category
Article
ISSN
8756-3282

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The runt family transcription factor (AML-3/PEBP2alphaA1/Cbfa1/RUNX2) plays a crucial role in formation of the mineralized skeleton during embryogenesis and regulates maturation of the osteoblast phenotype. Because steroid hormones and growth factors significantly influence growth and differentiatio