Stability analysis for the cavity-fillin
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Hidetoshi Kono; Minoru Saito; Akinori Sarai
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Article
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2000
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John Wiley and Sons
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English
โ 281 KB
We have analyzed the effect of cavity-filling mutations on protein stability by means of free-energy calculations based on molecular dynamics simulations to identify the factors contributing to stability changes caused by the mutations. We have studied the DNA-binding domain of Myb, which has a cavi