Caveolin regulation of neuronal intracellular signaling
β Scribed by Christopher M. Stern; Paul G. Mermelstein
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 284 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Caveolae are cholesterolβrich, membrane microdomains that appear critical to signaling between extracellular and intracellular macromolecules as well as cholesterol homeostasis. Caveolae formation is modulated by caveolin, a protein family that is the proteinaceous hallmark of caveolae.
A variety of signalling molecules has been implicated over the past 8 years in the regulation of intracellular transport pathways. Those molecules include heterotrimeric GTP binding proteins, members of the protein kinase C family, and members of the Rho subfamily of small GTPases. Until recently, n