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Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II

✍ Scribed by Akira Takaguri; Heigoro Shirai; Keita Kimura; Akinari Hinoki; Kunie Eguchi; MaryEllen Carlile-Klusacek; Baohua Yang; Victor Rizzo; Satoru Eguchi

Book ID: 116986229
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 861 KB
Volume: 50
Category: Article
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2010.12.009

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## Abstract Rat1 fibroblasts stably transfected with the rat angiotensin II (AngII) AT1a and bradykinin (BK) B2 receptor cDNAs gained the ability to bind Ang II and BK. Wild‐type Rat1 cells bound neither ligand. Exposure to either effector led to characteristic Gαi and Gαq signal cascades, the rele