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Caution in the interpretation of MLS

✍ Scribed by Sophie Eichenbaum-Voline; Emmanuelle Génin; Marie-Claude Babron; Patricia Margaritte-Jeannin; Bernard Prum; Françoise Clerget-Darpoux

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
38 KB
Volume
14
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

We study the statistical properties of the maximum likelihood score (MLS) test. We show that the criteria for reaching conclusions about linkage are not the same for single point analysis as for multipoint, where the maximization is performed over an additional parameter, the position in the marker interval where the MLS is computed. In addition, this test is shown to be very sensitive to errors in allele frequencies and recombination fraction.

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Interpretation of cytogenetic analysis in twins needs particular care and attention, as shown by the case of Johannsen et al. [2003], in which a child's ovaries were unnecessarily removed based on misleading cytogenetic information. Briefly, the authors reported a case of suspected monozygotic (MZ)