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Causes and consequences of acidic pH in tumors: a magnetic resonance study

โœ Scribed by Marion Stubbs; Paul M.J. McSheehy; John R. Griffiths


Book ID
117259423
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
227 KB
Volume
39
Category
Article
ISSN
0065-2571

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Tirapazamine is a hypoxic cell cytotoxin in phase II/III trials. To further understand its mechanism of action in vivo, we examined the effect of tirapazamine on tumor energy metabolism and pH. RIF-1 and SCCVII tumors were grown subcutaneously in the flanks of C3H mice. Tumor energy metabolism, expr