Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate †

On the role of the R configuration of th

On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 Å resolution

✍ Dušková, Jarmila ;Dohnálek, Jan ;Skálová, Tereza ;Petroková, Hana ;Vondráčková, 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 804 KB

Peptidomimetic inhibitors of human immunodeficiency virus-1 protease are successful lead substances for the development of virostatic drugs against HIV as the causative agent of acquired immunodeficiency syndrome (AIDS). The hydroxyethylamine isostere of the proteolytic cleavage intermediate provide