Catunaregin and Epicatunaregin, Two Norneolignans Possessing an Unprecedented Skeleton from Catunaregam spinosa

✍ Scribed by Guang-Chun Gao; Xiong-Ming Luo; Xiao-Yi Wei; Shu-Hua Qi; Hao Yin; Zhi-Hui Xiao; Si Zhang

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 189 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900193

✦ Synopsis

Abstract

Catunaregin (1) and epicatunaregin (2), two novel norneolignans with a unique O‐bridged furopyran ring, together with three known neolignans, ficusal, balanophonin, and 5″‐methoxy‐4″‐O‐(8‐guaiacylglycerol)buddlenol A, were isolated from the stem bark of Catunaregam spinosa, a Chinese mangrove associate. Their structures were elucidated by spectroscopic means, including two‐dimensional NMR techniques. Compounds 1 and 2 exhibited moderate inhibition against the mammary cancer F10 cell line.