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Cations and Hydration in Catalytic RNA: Molecular Dynamics of the Hepatitis Delta Virus Ribozyme

✍ Scribed by Krasovska, Maryna V.; Sefcikova, Jana; Réblová, Kamila; Schneider, Bohdan; Walter, Nils G.; Šponer, Jiří

Book ID
119920157
Publisher
Biophysical Society
Year
2006
Tongue
English
Weight
662 KB
Volume
91
Category
Article
ISSN
0006-3495

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Impact of an extruded nucleotide on clea
Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme
✍ Jana Sefcikova; Maryna V. Krasovska; Nad'a Špačková; Jiří Šponer; Nils G. Walter 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 770 KB

## Abstract The self‐cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal