✦ LIBER ✦

Cationic Metal–Corrole Complexes: Design, Synthesis, and Properties of Guanine-Quadruplex Stabilizers

✍ Scribed by Boqiao Fu; Dan Zhang; Xiaocheng Weng; Ming Zhang; Heng Ma; Yuzhi Ma; Xiang Zhou

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 396 KB
Volume: 14
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.200800835

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A series of pyridinium and quaternary ammonium copper corroles has been designed and synthesized. All new compounds have been fully characterized by NMR spectroscopy, high‐resolution mass spectrometry, UV/Vis spectrscopy, and elemental analysis. Biochemical studies have indicated that all of these corrole derivatives can stabilize G‐quadruplex structures, with corrole 4 being the most effective according to the results of circular dichroism (CD) melting experiments, polymerase chain reaction (PCR) stop assays, and surface plasmon resonance (SPR) experiments. Moreover, both corroles 3 and 4 tend to induce the human telomeric sequence to form hybrid G‐quadruplex structures, whereas corroles 8 and 9 are more inclined to induce the human telomeric sequence to form antiparallel G‐quadruplex structures.

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