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Cationic Gold(I)-Mediated Intramolecular Cyclization of 3-Alkyne-1,2-diols and 1-Amino-3-alkyn-2-ols: A Practical Route to Furans and Pyrroles

โœ Scribed by Egi, Masahiro; Azechi, Kenji; Akai, Shuji


Book ID
120080846
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
191 KB
Volume
11
Category
Article
ISSN
1523-7060

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A simple and convenient synthesis of sub
โœ Bartolo Gabriele; Pierluigi Plastina; Mabel V. Vetere; Lucia Veltri; Raffaella M ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 229 KB

A simple and economical synthesis of substituted furans and pyrroles, by ligand-free CuCl 2 -catalyzed heterocyclodehydration of readily available 3-yne-1,2-diols and N-Boc-or N-tosyl-1-amino-3-yn-2-ols, respectively, is presented. Reactions are carried out in MeOH at 80-100 ยฐC for 1-24 h and afford