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Cationic copolymers of ?,?-poly-(N-2-hydroxyethyl)-DL-aspartamide (PHEA) and ?,?-polyasparthylhydrazide (PAHy): synthesis and characterization

✍ Scribed by Giammona, Gaetano; Cavallaro, Gennara; Pitarresi, Giovanna; Pedone, Elisa

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
98 KB
Volume
49
Category
Article
ISSN
0959-8103

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✦ Synopsis

In the present study the derivatization of two water-soluble synthetic polymers, a,b-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) and a,b-polyasparthylhydrazide (PAHy), with glycidyltrimethylammonium chloride (GTA) is described. This reaction permits the introduction of positive charges in the macromolecular chains of PHEA and PAHy in order to make easier the electrostatic interaction with DNA. Different parameters affect the reaction of derivatization, such as GTA concentration and reaction time. PHEA reacts partially and slowly with GTA; on the contrary the reaction of PAHy with GTA is more rapid and extensive.

The derivatization of PHEA and PAHy with GTA is a convenient method to introduce positive groups in their chains and it permits the preparation of interpolyelectrolyte complexes with DNA.

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