Cation-Binding Location and Hydrogen-Exchange Sites for Gramicidin in SDS Micelles Using NOESY NMR
✍ Scribed by J.F. Hinton
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 124 KB
- Volume
- 112
- Category
- Article
- ISSN
- 1064-1866
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✦ Synopsis
The site of monovalent cation binding and sites of hydrogen of Na / ions the cation-binding site involves the Leu 10 , exchange between amide protons and water molecules in the gram-Leu 12 , and Leu 14 residues while the Trp 11 , Trp 13 , Gly 2 , icidin A and Phe-1 gramicidin A channels incorporated into SDS Ala 3 , Leu 4 , and Val 7 residues appear to be unaffected by micelles have been determined using a NOESY NMR technique. the Na / ions and, therefore, are not associated with cation The cation-binding pocket was found to involve residues 10-15 binding (21, 22). The discrepancy in binding site location of the peptide.