Catheter Effects in Organ Perfusion Experiments

✍ Scribed by YURI G. ANISSIMOV; ANTHONY J. BRACKEN; MICHAEL S. ROBERTS

• Book ID: 102613534
• Publisher: Elsevier Science
• Year: 2002
• Tongue: English
• Weight: 309 KB
• Volume: 214
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.2001.2450

✦ Synopsis

In a typical isolated organ perfusion experiment, a substance is injected upstream of an organ and then collected at some distance downstream. To reach the organ from the injection site, and then from the organ to the collector, a solute passes through catheters, usually tubes with circular cross-sections. Catheters cause distortion to the concentration}time pro"le of the perfusion. In this paper, we analyse catheter distribution kinetics from a mathematical point of view, develop the function most suitable for modeling this distribution and successfully apply this function to experimental data. 2002 Academic Press 0022}5193/02/020263#11 $35.00/0 D *C *r # 1 r *C *r # *C *x " *C *t #v(r) *C *x , (8)