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Cathepsin K inhibitors for the treatment of bone metastasis

✍ Scribed by E. Lindström*; L. Vrang; S. Sedig; Y. Terelius; B.-L. Sahlberg; K. Wikström; B. Samuelsson; T. Chambers; U. Grabowska


Book ID
116324064
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
49 KB
Volume
48
Category
Article
ISSN
8756-3282

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Cathepsin K inhibitors prevent bone loss
✍ Brenda L Pennypacker; Le T Duong; Tara E Cusick; Patricia J Masarachia; Michael 📂 Article 📅 2011 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 170 KB

## Abstract Two cathepsin K inhibitors (CatKIs) were compared with alendronate (ALN) for their effects on bone resorption and formation in ovariectomized (OVX) rabbits. The OVX model was validated by demonstrating significant loss (9.8% to 12.8%) in lumbar vertebral bone mineral density (LV BMD) in