Cathepsin K inhibitors for the treatment of bone metastasis
✍ Scribed by E. Lindström*; L. Vrang; S. Sedig; Y. Terelius; B.-L. Sahlberg; K. Wikström; B. Samuelsson; T. Chambers; U. Grabowska
- Book ID
- 116324064
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 49 KB
- Volume
- 48
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Two cathepsin K inhibitors (CatKIs) were compared with alendronate (ALN) for their effects on bone resorption and formation in ovariectomized (OVX) rabbits. The OVX model was validated by demonstrating significant loss (9.8% to 12.8%) in lumbar vertebral bone mineral density (LV BMD) in
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