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Cathepsin D, both a prognostic factor and a predictive factor for the effect of adjuvant tamoxifen in breast cancer

✍ Scribed by M. Fernö; B. Baldetorp; A. Borg; J.-P. Brouillet; H. Olsson; H. Rochefort; G. Sellberg; H. Sigurdsson; D. Killander

Book ID
118022817
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
941 KB
Volume
30
Category
Article
ISSN
0959-8049

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## Abstract The cell‐cycle regulating protein p27^Kip1^ (p27) has dual roles by acting as both a cdk inhibitor and as an assembly factor for different cdk complexes. Loss of p27 has been linked to malignant features in tumours; however, the exact role of p27 deregulation in breast cancer regarding