Amplification of the int-2 oncogene was measured in a series of breast tumours and related to amplification of the c-myc and c-erbB-2 oncogenes, histopathological features and relapse-free and overall survival. int-2 was amplified in I I%, c-myc in 20% and c-erbB-2 in 27% of the tumours assessed. in
Cathepsin D assay in primary breast cancer and lymph nodes: Relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness
✍ Scribed by Brouillet, Jean-Paul; Theillet, Charles; Maudelonde, Thierry; Defrenne, Annick; Simony-Lafontaine, Joëlle; Sertour, Jacqueline; Pujol, Henri; Jeanteur, Philippe; Rochefort, Henri
- Book ID
- 123492158
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 696 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0277-5379
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Background. Amplification of the c-erbB-2 protooncogene and DNA aneuploidy have been reported to correlate with poor patient prognosis in human breast cancer. Several studies have investigated the prognostic value of these two factors in heterogeneous populations of patients with node-positive and n
## BACKGROUND. Approximately 30% of breast carcinoma patients with negative lymph nodes die of their disease. Biologic markers such p53 protein and c-erb B-2 have been related to tumor progression, but their prognostic value remains controversial. ## METHODS. Two large series of a total of 613 ly