Cathepsin B Inhibitory Tetraene Lactones from the Fungus Talaromyces wortmannii

✍ Scribed by Yuesheng Dong; Jie Lin; Xinhua Lu; Zhihui Zheng; Xiao Ren; Hua Zhang; Jiangong He; Junshan Yang

• Book ID: 102256871
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: German
• Weight: 156 KB
• Volume: 92
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200800333

✦ Synopsis

Abstract

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Wortmannilactones E–H (1–4), four new cathepsin B inhibitors, were produced and isolated from the culture of the soil filamentous fungus Talaromyces wortmannii. Their structures and relative configurations were elucidated on the basis of 1D‐ and 2D‐NMR techniques, three of them (1, 2, and 4) posses an oxabicyclo[2.2.1]heptane moiety. Compounds 1–4 showed inhibitory activities against cathepsin B with IC~50~ values of 4.3, 6.5, 13.0, and 6.0 μM, respectively.