Catharanthus roseus: Current Research and Future Prospects

✍ Scribed by M. Naeem, Tariq Aftab, M. Masroor A. Khan (eds.)

Publisher: Springer International Publishing
Year: 2017
Tongue: English
Leaves: 414
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book studies the production of indole alkaloids in the important medicinal plant Catharanthus roseus (L.) G. Don, commonly known as periwinkle. The anticancer alkaloids, viz. vinblastine and vincristine, are mainly present in the leaves of C. roseus and inhibit the growth of cancer cells by hindering the formation of mitotic apparatus during cell division. Further, vinblastine helps increase the chance of surviving childhood leukemia while vincristine is used to treat Hodgkin’s disease. Great efforts have been made to produce these alkaloids at a large scale by the culture of plant cells. In view of this worldwide demand for commercial use, this book explores how to maximize the production of anticancer alkaloids from C. roseus. This reference book will be helpful for research students, teachers, ethnobotanists, pharmacologists and herbal growers who have a strong interest in this anticancer medicinal plant of paramount importance.

✦ Table of Contents

Front Matter....Pages i-xii
Strategies for Enhancing Alkaloids Yield in Catharanthus roseus Via Metabolic Engineering Approaches....Pages 1-16
In Vitro Biotechnological Production and Pharmacological Studies of Antileukemic Alkaloids of Catharanthus roseus ....Pages 17-34
Plant Efficacy and Alkaloids Production in Sadabahar (Catharanthus roseus L.): Role of Potent PGRs and Mineral Nutrients....Pages 35-57
Role of Biotechnology in Alkaloids Production....Pages 59-70
Agricultural, Pharmaceutical, and Therapeutic Interior of Catharanthus roseus (L.) G. Don....Pages 71-100
Elicitors Enhance Alkaloid Yield in Catharanthus roseus ....Pages 101-119
Catharanthus roseus: The Cancer-Fighting Medicine....Pages 121-151
In Vitro Studies, Biosynthesis of Secondary Metabolites and Pharmacological Utility of Catharanthus roseus (L.) G. Don.: A Review....Pages 153-199
Therapeutic Efficacy of Catharanthus roseus in Type 1 and Type 2 Diabetes Mellitus in Wistar Rats....Pages 201-246
Biotechnological Interventions to Modulate Terpenoid Indole Alkaloid Pathway in Catharanthus roseus Using In Vitro Tools and Approaches....Pages 247-275
Vincristine and Vinblastine Anticancer Catharanthus Alkaloids: Pharmacological Applications and Strategies for Yield Improvement....Pages 277-307
Role of PGRs in Anticancer Alkaloids (Vincristine and Vinblastine) Production....Pages 309-319
The Accumulation and Degradation of Alkaloids in Catharanthus roseus Supported by Various External Agents Under Different Environmental Conditions....Pages 321-329
Catharanthus roseus: Detoxification and Hepatic Protection of Aflatoxin B1....Pages 331-348
Potential of Catharanthus roseus (L.) in Phytoremediation of Heavy Metals....Pages 349-364
Unraveling the Cumulative Effect of Soil-Applied Radiation-Processed Sodium Alginate and Polyacrylamide on Growth Attributes, Physiological Activities, and Alkaloids Production in Periwinkle [Catharanthus roseus (L.) G. Don]....Pages 365-381
Catharanthus roseus: Cultivation Under Stress Conditions....Pages 383-397
The Study of the Effect of Nickel Heavy Metal on Some Growth Parameters and Production of Alkaloids in Catharanthus roseus ....Pages 399-412

✦ Subjects

Plant Anatomy/Development;Biomedical Engineering/Biotechnology;Pharmaceutical Sciences/Technology;Plant Genetics & Genomics;Plant Breeding/Biotechnology;Plant Systematics/Taxonomy/Biogeography

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