## Abstract Most leukemias that exhibit P‐glycoprotein (P‐gp)‐associated multidrug resistance (MDR) exhibit reduced susceptibility to immune cytotoxicity mediated by natural killer (NK) cells. To explore this phenomenon we investigated N6/ADR, a doxorubicin‐selected, P‐gp‐positive variant of the hu
Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells
✍ Scribed by Manfred Schedlowski; Anette Falk; Axel Rohne; Thomas O. F. Wagner; Roland Jacobs; Uwe Tewes; Reinhold E. Schmidt
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 857 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0271-9142
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## Abstract Fresh neoplastic B cells from 14 untreated patients with naturally occurring B‐cell leukemias were found to be susceptible to lysis by human natural killer (NK) cells. The observed lysis of the fresh, non‐cultured, neoplastic B cells was mediated by a population of interferon‐augmentabl
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