Catecholaminergic involvement in the effects of amphetamine isomers on seizure susceptibility
β Scribed by Michael C. Gerald; Tribhuwan K. Gupta
- Book ID
- 118322471
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 262 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0014-2999
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The amphetamine isomers impair the rotarod performance of rats in a dose-related manner, with (+)-amphetamine approximately four-times as potent as its (-)-isomer. At a rotation speed of 4 rpm, 60 min after i.p. administration, the TD50 values (mg/kg) were: (+)-amphetamine, 24 (21.9-26.4) and (-)-am
## Abstract Dosages of 0, 5, and 10 mg/kg body weight of dβamphetamine were injected subcutaneously to gravid albino rats during Days 5β9 or Days 12β16 of gestation. Offspring were assessed for waterβwading emotionality and audiogenicβseizure behaviors. No significant differences among groups were