Marked enantioselective protein binding
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Ph.D. Peter J. Hayball; Jeffrey W. Holman; Roger L. Nation; Ralph A. Massy-Westr
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Article
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1994
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John Wiley and Sons
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English
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The protein binding of the enantiomers of the nonopiate analgesic, ketorolac, was investigated in vitro using human plasma and solutions of human serum albumin (HSA) at physiological pH and temperature. In order to detect the very low levels of unbound enantiomers in protein solutions, tritium-label