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Catechol O-methyltransferase and indolethylamine N-methyltransferase activity in cerebrospinal fluid of dog, cat and human

✍ Scribed by N. Narasimhachari; R.-L. Lin


Book ID
118862381
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
248 KB
Volume
87
Category
Article
ISSN
0006-8993

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The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases