Catechol monoglyceryl ether carbamates

✍ Scribed by J. Swidinsky; J. Kervenski; B. B. Brown

• Book ID: 102398933
• Publisher: John Wiley and Sons
• Year: 1963
• Tongue: English
• Weight: 304 KB
• Volume: 52
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600521009

✦ Synopsis

A series of carbamates and N-methylcarbamates derived from 3-(o-hydroxyphenoxy)-1,2-propanediol was prepared and screened for muscle relaxant activity. An ester interchange between the above diol and diethyl carbonate failed to give 4-(o- hydroxyphenoxymethyl)-~y3-dioxolone-2; 2-hydroxymethyl-l,4-benzodioxane was obtained instead. Prior bemylation of the phenolic hydroxyl resulted in the normal formation of the dioxolone. None of fhe compounds possessed muscle relaxant acuvity.

HE SUCCESS of 3-(uo-methoxyphenoxy)-2-Thydroxy-l-propyl carbamate, methocarbamol' as a muscle relaxant prompted evaluation of similar activity in carbamates derived from the monoglycerol ether of catechol, 3-(o-hydroxyphenoxy)-l,2-propanediol (1).