Catalytic ring opening of substituted 2-oxetanones
β Scribed by Noels, A. F.; Herman, J. J.; Teyssie, P.
- Book ID
- 126995359
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 631 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Summar~~: Intermolecular 2 + 2 aldehyde-ketene cycloaddition, followed by Lewis acid induced intramolecular ring opening of the 2-oxetanone product have been used to prepare tetrahydrofuran and tetrahydropyran ring systems. Among lactones, 2-oxetanones are characterized by their readiness to underg
## Abstract **Cooperative metal centers** in a bimetallic catalyst facilitate the highly enantioselective ring opening of __meso__ aziridines **1** with silyl nucleophiles (see scheme; TMS=trimethylsilyl). The 1,2βazidoamides **2** and 1,2βamidonitriles **3** obtained in this way in high yields and