Catalytic oxidation and flow detection of acetaminophen at a dicyanobis(1,10-phenanthroline)iron(II)-modified electrode

✍ Scribed by Huimei Li; Rile Ge; Erkang Wang

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 421 KB
• Volume: 292
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(94)00033-6

✦ Synopsis

Dicyanobis(l,lO-phenanthroline)iron(II)-modified glassy carbon electrodes were shown to exhibit an electrocatalytic response for the oxidation of acetaminophen with a decrease of 100 mV in the potential required. It can also inhibit the oxidation of ascorbic acid and uric acid. When used for amperometric monitoring of acetaminophen in a flowing stream, the coated electrode may permit detection at lower potentials compared with the naked surface. The method gives a linear range from 0.05 to 100 pg ml-' and a detection limit of 0.02 pg ml-' (signal-to-noise ratio = 2). The application of the method to the determination of acetaminophen in urine by LC is briefly described.