Catalytic monoalkylation of 1,2-diols

✍ Scribed by Toshihide Maki; Nobuto Ushijima; Yoshihiro Matsumura; Osamu Onomura

• Book ID: 104096197
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 586 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.01.063

✦ Synopsis

A catalytic monoalkylation of 1,2-diols by using a weak base has been developed. Copper(II) dichloride and boronic acids are effective catalysts for activating 1,2-diols in the presence of potassium carbonate as a base. Various 1,2-diols were selectively monoalkylated with allyl-, benzyl-and alkyl-halides in DMF by choosing a suitable catalyst for each 1,2-diols.