Computational studies of the domain move
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Steven W. Rick; Yuri G. Abashkin; Richard L. Hilderbrandt; Stanley K. Burt
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Article
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1999
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John Wiley and Sons
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English
⚖ 400 KB
👁 2 views
Thymidine phosphorylase (TP) is a dual substrate enzyme with two domains. Each domain binds a substrate. In the crystal structure of Escherichia coli TP, the two domains are arranged so that the two substrate binding sites are too far away for the two substrates to directly react. Molecular dynamics