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Catalytic inhibitors of DNA topoisomerase II

โœ Scribed by Toshiwo Andoh; Ryoji Ishida


Book ID
114148333
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
387 KB
Volume
1400
Category
Article
ISSN
0167-4781

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Catalytic inhibitors of topoisomerase II
โœ Ling Wang; David A. Eastmond ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 182 KB

Merbarone is a catalytic inhibitor of topoisomerase II (topo II) that has been proposed to act primarily by blocking topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. In this study merbarone was used as a model compound to investigate the genotoxic effects of catalyt