Catalytic hydroxylation on aromatic rings by use of an artificial P-450 system assisted by acid and acid anhydride.

✍ Scribed by Iwao Tabushi; Kozo Morimitsu

• Book ID: 104218051
• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 221 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)83937-4

✦ Synopsis

Aromatic compounds are effectively monohydroxylated by the artificial P-450 type catalytic system, consisting of TPPeMn, N-methylimidazole, colloidal Pt, O2 and H2.

Addition of benzoic anhydride and/or hydrogen chloride favored oand p-hydroxylation.

The accumulation

of valuable structural and mechanistic information on monooxygenation through dioxygen activation by native cytochrome P-450" allows one to design a system consisting of totally artificial molecules which mimicks the efficient biological monooxygenation reaction 2) . In addition, several carefully designed systems which produce P-450 type activity via oxygen atom transfer have been reported recently 3) . Among the monooxygenation reactions studied by the use of these artificial P-450 type systems, hydroxyla-