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Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif

✍ Scribed by Zhang, Zhong-Yin; Palfey, Bruce A.; Wu, Li; Zhao, Yu


Book ID
127109660
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
918 KB
Volume
34
Category
Article
ISSN
0006-2960

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Previous studies in this laboratory have shown that the SH-2 domaincontaining protein tyrosine phosphatase SHP-1 is expressed in CNS glia and functions to modulate cytokine activities in these cells. The present study demonstrates that SHP-1 is expressed within multiple regions of the CNS in vivo, e