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Catalytic enantioselective protonation of samarium enolates by a C2-symmetric chiral diol

✍ Scribed by Yutaka Nakamura; Seiji Takeuchi; Akiko Ohira; Yoshiaki Ohgo


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
225 KB
Volume
37
Category
Article
ISSN
0040-4039

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Chiral C2-symmetric DMEU derivatives were designed and synthesized as chiral ligands for lithium. The reaction of the lithium enolate (2) of 1-tetralone (1) with methyl iodide in toluene in the presence of a DMEU derivative (11) and hexamethyldisilazane gave (S)-2-methyl-l-tetralone ((S)-3) in up to