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Catalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine A

✍ Scribed by Buyck, Thomas; Wang, Qian; Zhu, Jieping

Book ID
121379150
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
466 KB
Volume
52
Category
Article
ISSN
0044-8249

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Enantioselective synthesis of α,α-disubs
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✍ AndréB Charette; Christophe Mellon 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 683 KB

The sequential addition of two different nucleophiles to a tartaric acid-derived nitrile produced carbinamines. The adducts from chelation-controlled addition which are obtained in high diastereoselectivities and yields, were easily converted to ct,ct-disubstituted-t~-amino acids.