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Catalytic Enantioselective Approach to the Eudesmane Sesquiterpenoids: Total Synthesis of (+)-Carissone

✍ Scribed by Levine, Samantha R.; Krout, Michael R.; Stoltz, Brian M.


Book ID
120049305
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
171 KB
Volume
11
Category
Article
ISSN
1523-7060

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New enantioselective approach to the tot
✍ Almudena Rubio; JesΓΊs Ezquerra; Ana Escribano; Modesto JesΓΊs RemuiΓ±Γ‘n; Juan JosΓ© πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 269 KB

The total synthesis of (-)-ot-Kainic Acid 1 has been accomplished using ethyl N-Bocpyroglutamate 2 as starting material. The isopropenyl appendage was achieved from the elimination of the dimethylcarbinol introduced at C-4 via an aldol condensation of the lactam enolate of 2 and acetone. The acetate