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Catalytic Enantioselective Aldol Reaction to Ketones

โœ Scribed by Oisaki, Kounosuke; Zhao, Dongbo; Kanai, Motomu; Shibasaki, Masakatsu


Book ID
127374619
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
87 KB
Volume
128
Category
Article
ISSN
0002-7863

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Catalytic Enantioselective Aldol Reactio
โœ Oisaki, Kounosuke; Zhao, Dongbo; Kanai, Motomu; Shibasaki, Masakatsu ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 87 KB

An enantioselective aldol reaction between ketones and ketene silyl acetals is described using CuF-chiral phosphine as a catalyst. The key for high enantioselectivity was the development of a novel ligand derived from Taniaphos combined with the unique accelerative effect of PhBF3K. These conditions