Catalytic Diastereoselective Synthesis of Diquinanes from Acyclic Precursors.
โ Scribed by Jian-Cheng Wang; Sze-Sze Ng; Michael J. Krische
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 106 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A number of 8โhydroxyโ6โmethylโ1,6โnaphthyridinโ5(6__H__)โoneโ7โcarboxylic acid alkyl esters 3 and the isomeric 5โhydroxyโ7โmethylโ1,7โnaphthyridinโ8(7__H__)โoneโ6โcarboxylic acid alkyl esters 4 were synthesized from acyclic precursors obtained starting from quinolinic anhydride 5. Thus
A convenient diastereoselective synthesis of an immediate high yielding new type of Pd(0) catalyzed cyclization of a suitable hydrazine derivative together with a stereospecific precursor for a rapid access to a variety of homo-carbocyclic nucleosides, is described. The synthetic scheme involves a O