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Catalytic components of proteasomes and the regulation of proteinase activity

✍ Scribed by A. Jennifer Rivett; Grant G. F. Mason; Stuart Thomson; Angela M. Pike; Peter J. Savory; Rachael Z. Murray


Publisher
Springer
Year
1995
Tongue
English
Weight
673 KB
Volume
21
Category
Article
ISSN
0301-4851

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The proteasome is an important multicatalytic enzyme complex that degrades misfolded and oxidized proteins, signal transduction factors, and antigenic peptides for presentation. We investigated the in vitro effects of peroxynitrite (PN) on the peptidase activity of both crude 20S and 26S and purifie