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Catalytic Asymmetric Synthesis of (S)-Acetophenone Cyanohydrin under High Pressure

✍ Scribed by Michael C.K Choi; S.S Chan; Kiyoshi Matsumoto

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 425 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01561-x

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✦ Synopsis

The first trimethylsilylcyanationof acetophenoneto its (S)-cyanohydrinwas accomplished with e.e. up to 60% in 93% yield at 0.8 GPa, using 0.01 eq. of a reuseablecatalystpreparedfrom (S')-3,3-dimethyl-1,2,4-butanetriol and titarriumisopropoxide.Reactions of 4'-substitutedacetophenonesto the correspondingcyanohydrinsgave lowere.e. and yields. @ 1997Elsevier ScienceLtd.

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