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Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity

✍ Scribed by Kobayashi, Shū; Ueno, Masaharu; Suzuki, Ritsu; Ishitani, Haruro; Kim, Hye-Sook; Wataya, Yusuke

Book ID
126126702
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
132 KB
Volume
64
Category
Article
ISSN
0022-3263

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Catalytic asymmetric synthesis of febrif
Catalytic asymmetric synthesis of febrifugine and isofebrifugine
✍ Shū Kobayashi; Masaharu Ueno; Ritsu Suzuki; Haruro Ishitani 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 201 KB

Antimalarial alkaloids, febrifugine (1) and isofebrifugine (2), were synthesized from simple achiral starting materials using tin(lI)-catalyzed catalytic asymmetric aldol reaction and lanthanide-catalyzed aqueous three-component reaction as the key steps. These unambiguous total syntheses revealed t