Catalytic Asymmetric Synthesis, 3rd Edition

✍ Scribed by Iwao Ojima

• Publisher: Wiley
• Year: 2010
• Tongue: English
• Leaves: 1018
• Edition: 3
• Category: Library

✦ Synopsis

Praise for the previous editions"An excellent text . . . will no doubt provide the benchmark for comparative works for many years." —Journal of the American Chemical Society"An excellent state-of-the-art compilation of catalytic asymmetric chemistry . . . should be included in any chemistry reference collection." —Choice"This is a tremendous resource and an excellent read. I recommend immediate purchase." —Perkin TransactionsSince this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields—from medicine to materials science. Catalytic Asymmetric Synthesis, Third Edition addresses these rapid changes through contributions from highly recognized world leaders in the field.This seminal text presents detailed accounts of the most important catalytic asymmetric reactions known today, and discusses recent advances and essential information on the initial development of certain processes. An excellent working resource for academic researchers and industrial chemists alike, the Third Edition features:Six entirely new chapters focusing on novel approaches to catalytic asymmetric synthesis including non-conventional media/conditions, organocatalysis, chiral Lewis and Bronsted acids, CH activation, carbon-heteroatom bond-forming reactions, and enzyme-catalyzed asymmetric synthesisA new section focusing on the important new reaction, asymmetric metathesis, in carbon-carbon bond-forming reactionsUpdated chapters on hydrogenation, carbon-carbon bond-forming reactions, hydrosilylations, carbonylations, oxidations, amplifications and autocatalysis, and polymerization reactionsRetaining the best of its predecessors but now thoroughly up to date, Catalytic Asymmetric Synthesis, Third Edition serves as an excellent desktop reference and text for researchers and students from the upper-level undergraduates through experienced professionals in industry or academia.

✦ Table of Contents

CATALYTIC ASYMMETRIC SYNTHESIS......Page 3
CONTENTS......Page 7
Preface......Page 11
Preface to the Second Edition......Page 13
Preface to the First Edition......Page 15
Contributors......Page 17
1 Catalytic Asymmetric Synthesis in Nonconventional Media/Conditions......Page 21
2 Asymmetric Organocatalysis......Page 57
2A Enantioselective Organocatalysis Involving Iminium, Enamine, SOMO, and Photoredox Activation......Page 59
2B Asymmetric Acid–Base Bifunctional Catalysis with Organic Molecules......Page 79
2C Asymmetric Phase-Transfer and Ion Pair Catalysis......Page 115
3 Chiral Lewis Acids and Brønsted Acids in Asymmetric Synthesis......Page 139
4 Asymmetric Synthesis through C–H Activation......Page 183
5 Asymmetric Carbon–Heteroatom Bond-Forming Reactions......Page 247
6 Enzyme-Catalyzed Asymmetric Synthesis......Page 289
7 Transition Metal-Catalyzed Homogeneous Asymmetric Hydrogenation......Page 363
8 Asymmetric Carbon–Carbon Bond-Forming Reactions......Page 457
8A Catalytic Asymmetric Conjugate Addition......Page 459
8B Enantioselective Allylic Substitutions with Carbon Nucleophiles......Page 517
8C Asymmetric Carbometallation and Carbocyclizations......Page 663
8D Asymmetric Ene Reactions and Cycloadditions......Page 703
8E Catalytic Enantioselective Olefin Metathesis Reactions......Page 759
9 Asymmetric Hydrosilylation of Carbon–Carbon Double Bonds and Related Reactions......Page 791
10 Asymmetric Carbonylations......Page 819
11 Asymmetric Oxidations and Related Reactions......Page 859
12 Asymmetric Amplification and Autocatalysis......Page 911
13 Asymmetric Polymerization......Page 951
Index......Page 1007