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Catalytic Asymmetric Mono-Fluorination of α-Keto Esters: Synthesis of Optically Active β-Fluoro-α-Hydroxy and β-Fluoro-α-Amino Acid Derivatives

✍ Scribed by Dr. Shoko Suzuki; Dr. Yuki Kitamura; Dr. Sylvain Lectard; Dr. Yoshitaka Hamashima; Prof. Dr. Mikiko Sodeoka


Book ID
111643147
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
535 KB
Volume
51
Category
Article
ISSN
0044-8249

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ChemInform Abstract: Synthesis of α-Fluo
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Synthesis of α-Fluoro-β-keto Phosphonates from α-Fluoro Phosphonoacetic Acid. -A new method for the preparation of α-fluoro-β-keto phosphonates (III) (8 examples), valuable intermediates in the organic synthesis, based on the acylation of α-fluoro phosphonoacetic acid (I) with carboxylic acid chlor