Catalytic Asymmetric Conjugate Reactions (CORDOVA:ASYM CONJUG ADDIT O-BK) || Catalytic Asymmetric Baylis-Hillman Reactions and Surroundings
✍ Scribed by Córdova, Armando
- Publisher
- Wiley-VCH Verlag GmbH & Co. KGaA
- Year
- 2010
- Tongue
- German
- Weight
- 577 KB
- Edition
- 1
- Category
- Article
- ISBN
- 3527324119
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✦ Synopsis
The Reaction Mechanism
Although the first arrow-pushing mechanism was reported by Hoffman and Rabe in 1986 [6], Hill and Isaacs [7] later proposed the commonly accepted mechanism Catalytic Asymmetric Conjugate Reactions.
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Scheme 9.1 The Weitz-Scheffer epoxidation. alkenes requires the formation of nucleophilic oxidative species. The first example of the epoxidation of α,β-unsaturated carbonyl compounds was reported by Weitz and Scheffer in 1921 (Scheme 9.1) [16]. This two-step process first involves the conjugate a