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Catalytic Asymmetric Conjugate Addition of Dialkylzinc Reagents to β-Aryl-α,β-unsaturated N -2,4,6-Triisopropylphenylsulfonylaldimines with Use of N -Boc- l -Val-Connected Amidophosphane-Copper(I) Catalyst

✍ Scribed by Soeta, Takahiro; Kuriyama, Masami; Tomioka, Kiyoshi


Book ID
126047495
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
98 KB
Volume
70
Category
Article
ISSN
0022-3263

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Copper(I) phosphoramidite catalyzed asym
✍ Jos P.G. Versleijen; Albert M. van Leusen; Ben L. Feringa 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 241 KB

The asymmetric copper(I) phosphoramidite catalyzed conjugate addition of dialkylzinc reagents to E,Zmixtures of et,13-unsaturated nitroacetates provided the 1,4-adducts in excellent yields but with low e.e.'s. High enantioselectivities (e.e.'s up to 92%) were obtained with structurally rigid 3-nitro